Most lymphocytes of the T cell lineage develop along the CD4/CD8 pathway and express antigen receptors on their surfaces consisting of clonotypic αβ chains associated with invariant CD3‐γδε components and ζ chains, collectively referred to as the T cell antigen receptor complex (TCR). Expression of the TCR complex is dynamically regulated during T cell development, with immature CD4+CD8+ thymocytes expressing only 10% of the number of αβ TCR complexes on their surfaces expressed by mature CD4+ and CD8+ T cells. Recent (...) evidence demonstrates that low surface TCR density on CD4+CD8+ thymocytes results from the limited survival of a single TCR component within the ER, the TCRα chain, which has a half life of only 15 minutes in immature thymocytes, compared to >75 minutes in mature T cells. Instability of TCRα proteins in immature CD4+CD8+ thymocytes represents a novel mechanism by which expression of the multisubunit TCR complex is quantitatively regulated during T cell development. In the current review we discuss our recent findings concerning the assembly, intracellular transport, and expression of αβ TCR complexes in CD4+CD8+ thymocytes and comment on the functional significance of TCRα instability during T cell development. (shrink)

This paper develops a soft-libertarian response to Frankfurt-style cases and to the threat that such cases apparently pose to any brand of libertarianism.

Almost thirty years ago, in an attempt to undermine what he termed “the principle of alternate possibilities”.

Almost thirty years ago, in an attempt to undermine what he termed "the principle of alternate possibilities" (the thesis that people are morally responsible for what they have done only if they could have done otherwise), Harry Frankfurt offered an ingenious thought-experiment that has played a major role in subsequent work on moral responsibility and free will. Several philosophers, including David Widerker and Robert Kane, argued recently that this thought-experiment and others like it are fundamentally flawed. This paper develops a (...) new Frankfurt-style example that is immune to their objections. [Reprinted in Laura Waddell Ekstrom, ed., Agency and Responsibility: Essays on the Metaphysics of Freedom (Westview Press, 2001), pp. 241-54; and in John Martin Fischer, ed., Free Will, Vol. III (Routledge, 2005), pp. 330-42.]. (shrink)

This chapter clarifies principles of alternative possibilities both for moral responsibility and for free action, locates the most important challenge that Frankfurt-style cases pose for libertarianism, and begins to develop an answer to that challenge.

In this paper Mele and Robb defend their (1998) paper against a variety of objections and further their develop their defense of Frankfurt-style cases.

This critical examination of Roderick Chisholm's agent causal brand of libertarianism develops a problem about luck that undermines his earlier and later libertarian views on free will and moral responsibility and defends the thesis that a modest libertarian alternative considerably softens the problem. The alternative calls for an indeterministic connection in the action-producing process that is further removed from action than Chisholm demands. The article also explores the implications of a relatively new variant of a Frankfurt-style case for Chisholm's views (...) of free will and moral responsibility and for libertarianism in general. It is suggested that Chisholm's efforts will and should continue to offer important assistance to libertarians who are determined to succeed where he apparently fell short. (shrink)

Is it appropriate to honour and admire people who have created great works of art, made important intellectual contributions, performed great sporting feats or shaped the history of a nation if those people have also acted immorally? This book provides a philosophical investigation of this important and timely question. -/- The authors draw on the latest research from ethics, value theory, philosophy of emotion, social philosophy and social psychology to develop and substantiate arguments that have been made in the public (...) debates about this issue. They offer a detailed analysis of the nature and ethics of honour and admiration, and present reasons both in favor and against honouring and admiring the immoral. They also take on the important matter of whether we can separate the achievements of public figures from their immoral behavior. Ultimately, the authors reject a "one-size-fits-all" approach and argue that we must weigh up the reasons for and against honouring and admiring in each particular case. -/- Honouring and Admiring the Immoral is written in an accessible style that shows how philosophy can engage with public debates about important ethical issues. It will be of interest to scholars and students working in moral philosophy, philosophy of emotion, and social philosophy. (shrink)

Humanist sociologists are activists rooted in the reality of history and change and guided by a concern for the 'real life' problems of equality, peace, and social justice. They view people as active shapers of social life, capable of creating societies in which everyone's potential can unfold. Alfred McClung Lee introduces this volume with 'Sociology: Humanist and Scientific' and develops the theme that a sociology that is humanist is also scientific. The other nine selections are grouped into four parts: (...) 'The Individual and Social Life;' 'Social Institutions: Technology, Science, and Formal Organization;' 'Political Structures: Issues of Justice and Equality;' and 'Methodological Critiques and Counterproposals.'. (shrink)

One popular style of argument for the thesis that determinism is incompatible with moral responsibility features manipulation. Its thrust is that regarding moral responsibility, there is no important difference between various cases of manipulation in which agents who A are not morally responsible for A-ing and ordinary cases of A-ing in deterministic worlds. There is a detailed argument of this kind in Derk Pereboom’s recent book (2001: 112–26). His strategy in what he calls his ‘four-case argument’ (117) is to describe (...) three cases of progressively weaker manipulation in which, he contends, the agent, Plum, is not morally responsible for killing his victim and to compare them to a related deterministic case that involves no manipulation. Pereboom argues that what blocks Plum’s moral responsibility for the killing in the first three cases is the fact that ‘his action results from a deterministic causal process that traces back to factors beyond his control’ and that, because this fact also obtains in the fourth case, Plum is not morally responsible for that killing either (116). My thesis is that Pereboom’s argument fails. (shrink)

In this chapter, drawing partly on some attractions to soft libertarianism and on a libertarian approach articulated in Mele (1996) to accommodating successful Frankfurt-style cases, I motivate the thesis that at least some human beings sometimes act freely than that no human being ever acts freely.

Teleological explanations of human actions are explanations in terms of aims, goals, or purposes of human agents. According to a familiar causal approach to analyzing and explaining human action, our actions are, essentially, events (and sometimes states, perhaps) that are suitably caused by appropriate mental items, or neural realizations of those items. Causalists traditionally appeal, in part, to such goal-representing states as desires and intentions (or their neural realizers) in their explanations of human actions, and they take accept-able teleological explanations (...) of our actions to be causal explanations. Some proponents of the view that human actions are explained teleologically resist this. They regard the causal approach as a rival. I dub this position “anticausalist teleologism,” or AT, for short. I favor the causal approach, but I will not directly argue for it here. My aim is more modest. I will develop a serious problem for AT that strongly suggests that teleologists need causalism; and I will rebut a style of objection to the project of providing a causal analysis of acting in pursuit of a goal that recently resurfaced in the literature on teleological explanations of action, a style of objection featuring a certain kind of causal deviance. (shrink)

Frankfurt‐style action cases have been immensely influential in the free will and moral responsibility literatures because they arguably show that an agent can be morally responsible for a behavior despite lacking the ability to do otherwise. However, even among the philosophers who accept Frankfurt‐style action cases, there remains significant disagreement about whether also to accept Frankfurt‐style omission cases – cases in which an agent omits to do something, is unable to do otherwise, and is allegedly morally responsible for that omission. (...) Settling this debate about Frankfurt‐style omission cases is significant because the resolution entails an important fact about moral responsibility: whether there is there a moral asymmetry between actions and omissions with respect to the ability to do otherwise. My proposal is that both Frankfurt‐style action cases and omission cases involve the same type of causal structure: causal preemption. However, the preemptor and the preemptee differ. In action cases, the Frankfurted agent preempts the neuroscientist and is causally and morally responsibility for the effect. In omission cases, Frankfurted agent is neither causally nor morally responsible for the effect. Instead, the neuroscientist preempts the Frankfurted agent. Thus, there are no Frankfurt‐style omission cases. (shrink)

The arguments against the existence of Īśvara that are advanced by Śālikanātha’s Prakaraṇapañcikā are quite peculiar and cryptic, due to both the idiosyncratic nature and opaque style of Śālikanātha’s writing. This has contributed to the difficulty in identifying the actual nature of the views that Śālikanātha opposes. This article analyses the framework by which Śālikanātha interrogates the concept of Īśvara and discusses the possible sources of his arguments. It shows, contrary to the conclusions of past scholarship, that considerations of both (...) Nyāya and Vaiśeṣika sources are certainly apparent in Śālikanātha’s formulation of his critique of Īśvara. This paper also discusses the possible sources from which Śālikanātha derives the notion of Īśvara as the creator of the Vedas. It concludes that rather than any Nyāya or Vaiśeṣika sources, it is most likely that Śālikanātha derives this notion of Īśvara from Kumārila, who potentially has Yoga opponent in mind. (shrink)

Alfred Tarski’s refinement of an account of truth into a formal system that turns on the acceptance of Convention-T has had a lasting impact on philosophical logic, especially work concerning truth, meaning, and other semantic notions. In a series of studies completed from the 1930s to the 1960s, Arne Næss collected and analysed intuitive responses from non-philosophers to questions concerning truth, synonymy, certainty, and probability. Among the formulations of truth studied by Næss were practical variants of expressions of the (...) form “p’ is true if and only if p’. This paper calls attention to a series of experimental results Næss overlooked in his original study. These data collectively suggest that acceptance of expressions of the form “p’ is true if and only if p’ varies according to what kind of statement p is. (shrink)

Behavioral scientists routinely publish broad claims about human psychology and behavior in the world's top journals based on samples drawn entirely from Western, Educated, Industrialized, Rich, and Democratic (WEIRD) societies. Researchers – often implicitly – assume that either there is little variation across human populations, or that these “standard subjects” are as representative of the species as any other population. Are these assumptions justified? Here, our review of the comparative database from across the behavioral sciences suggests both that there is (...) substantial variability in experimental results across populations and that WEIRD subjects are particularly unusual compared with the rest of the species – frequent outliers. The domains reviewed include visual perception, fairness, cooperation, spatial reasoning, categorization and inferential induction, moral reasoning, reasoning styles, self-concepts and related motivations, and the heritability of IQ. The findings suggest that members of WEIRD societies, including young children, are among the least representative populations one could find for generalizing about humans. Many of these findings involve domains that are associated with fundamental aspects of psychology, motivation, and behavior – hence, there are no obviousa priorigrounds for claiming that a particular behavioral phenomenon is universal based on sampling from a single subpopulation. Overall, these empirical patterns suggests that we need to be less cavalier in addressing questions ofhumannature on the basis of data drawn from this particularly thin, and rather unusual, slice of humanity. We close by proposing ways to structurally re-organize the behavioral sciences to best tackle these challenges. (shrink)

What role do celebrities play in our moral lives? Philosophers have explored the potential for celebrities to function as moral exemplars and role models. We argue that there are more ways in which celebrities play a role in helping us navigate our moral lives. First, gossiping about celebrities helps us negotiate our moral norms and identify competing styles of life. Second, fandom for celebrities serves as the basis for the development of distinct moral communities and identities. Third, celebrities possess (...) high levels of epistemic power which can be used to help change and adapt our moral norms. We will then investigate two kinds of problems that arise from using celebrities in this way. Firstly, harm is done to celebrities because they are used in the ways explained in the first part of the article; secondly, celebrity life has a distinctive nature that can affect the moral agency of celebrities. Fame, we suggest, might lead to a morally unhealthy asymmetry in human relationships. We end by discussing the ethical implications of our analysis and conclude that when using stars for moral navigation, we should take into account the harm this does to them and the distinctive nature of their lives. (shrink)

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain (...) in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

Book reviewed in this article: How We Die. By Sherwin B. Nuland. New York: Alfred A. Knopf.

Alfred Tarski seems to endorse a partial conception of truth, the T-schema, which he believes might be clarified by the application of empirical methods, specifically citing the experimental results of Arne Næss (1938a). The aim of this paper is to argue that Næss’ empirical work confirmed Tarski’s semantic conception of truth, among others. In the first part, I lay out the case for believing that Tarski’s T-schema, while not the formal and generalizable Convention-T, provides a partial account of truth (...) that may be buttressed by an examination of the ordinary person’s views of truth. Then, I address a concern raised by Tarski’s contemporaries who saw Næss’ results as refuting Tarski’s semantic conception. Following that, I summarize Næss’ results. Finally, I will contend with a few objections that suggest a strict interpretation of Næss’ results might recommend an overturning of Tarski’s theory. (shrink)

In the final chapter of her Causation and Free Will, Carolina Sartorio offers a novel reply to an original-design argument for the thesis that determinism is incompatible with free will and moral responsibility, an argument that resembles Alfred Mele’s zygote argument in Free Will and Luck. This article assesses the merits of her reply. It is concluded that Sartorio has more work to do if she is to lay this style of argument to rest.

Traditional theorists about free will and moral responsibility endorse the principle of alternative possibilities (PAP): an agent is morally responsible for an action that she performs only if she can do or could have done otherwise. According to source theorists, PAP is false and an agent is morally responsible for her action only if she is the source of that action. Source incompatibilists accept the source theory but also endorse INC: if determinism is true, then no one is morally responsible (...) for any action. This paper is a critique of a kind of source incompatibilism, namely, direct source incompatibilism. Direct source incompatibilists reject PAP on the basis of Frankfurt-style examples. Since PAP is one of two premises in the traditional argument for INC, direct source incompatibilists opt for a version of the direct argument, which argues for INC with the aid of some non-responsibility transfer principle. I demonstrate that this option is not available, for there is a tension between the following two claims. (shrink)